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proposed in 1906 that the duodenal mucosa might secrete a hormonal substance, which would affect the disposal of glucose from the blood by acting as a chemical excitant for the internal secretion of the pancreas and tried to treat diabetes (not very successfully) by injections of gut extracts (1)

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doi: 10.1016/j.fertnstert.2009.12.039 63 AgarwalAParekhNSelvamMKPHenkelRShahRHomaSTet al

"It's basically a tailored approach to dosing Ozempic to meet the needs of the individual," says Dr